GENTISYL ALCOHOL INHIBITS PROLIFERATION AND INDUCES APOPTOSIS VIA MITOCHONDRIAL DYSFUNCTION AND REGULATION OF MAPK AND PI3K/AKT PATHWAYS IN EPITHELIAL OVARIAN CANCER CELLS

Ovarian cancer is one of the prevalent gynecological cancers occurring in women.In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue.To assist standard anti-cancer agents in the cure of ovarian cancer, development and Disinfectant application of new compounds such as small molecules or na

Abstract Background Nanotechnology has the potential to reduce drug dosage while increasing efficacy; thus, the current work intends to synthesize diclazuril nanoemulsion and assess its performance against experimental coccidiosis in broilers.Methods Diclazuril nanoemulsion (DZN) was formulated and characterized by zeta seizer and zeta potential.Th

ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen that can salvage nucleobases from the environment to conserve nutrients that would otherwise be spent on de novo nucleotide biosynthesis.However, little is known regarding the substrate specificity of the 13 putative nucleobase transporters in P.aeruginosa.Here, using a combination of gen

Background: Mediterranean form of visceral leishmaniasis (VL) is endemic among some provinces of Iran.The pre­sent study was designed to determine the prevalence of canine visceral leishmaniasis (CVL) in the owned dogs of the rural areas of Alborz Province near Tehran as the capital of Iran.Methods: This study conducted on 303 owned dogs that sele